A number of microRNAs can repress translation of Twist1, a proto-oncogene whose upregulation is linked to resistance to cancer drugs, report Aarhus University researchers in PLOS One. In a number of cell lines, the researchers found that miR-145a-5p, miR-151-5p and a combination of miR-145a-5p and miR-151-5p or of miR-151-5p and miR-337-3p could repress the expression of the oncogene.