This Week in PLoS

In a paper in PLoS Genetics, scientists looked across two populations to find that "increases in mobility, urbanization, and cross-population mating over the last century have substantially reduced inbreeding, and left a distinctive trace in the genome of modern Americans," blogger Daniel MacArthur says at Genetic Future.

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The US Food and Drug Administration has approved Alnylam's RNAi-based therapy Onpattro, according to Stat News.

Harvard Medical School's Seth Cassel and Cigall Kadoch argue in a Baltimore Sun op-ed that the recent TAILORx trial shows the potential of genomic-based medicine.

Researchers in the UK are working on using gene drives to control malaria-carrying mosquitoes, the Telegraph reports.

In PLOS this week: genetic architecture mediating gene expression, metabolomic patterns in multiple myeloma, and more.