Skip to main content
Premium Trial:

Request an Annual Quote

This Week in PLOS: Jan 1, 2013

In PLOS One, Case Western Reserve University's Jing Li and colleagues from that center's electrical engineering and computer science department describe a method for predicting the presence of structural variation from paired-end, high-throughput sequence data. The approach, dubbed SVMiner, uses a model-based clustering approach to define a range of candidate structural variants from paired-end sequence data given structural variant features. For the new study, the investigators highlighted the feasibility of this approach for finding structural variants in both simulated and real datasets.

A team from the US and Belgium took a systems-based approach to define the gene networks that control bone-related cells in the osteoblast lineage. As they report in PLOS Genetics, the researchers used array-based bone gene expression information on inbred mouse strains from the Hybrid Mouse Diversity Panel, combined with related genomic data, to define modules of co-expressed genes contributing to various aspects of skeletal growth and development, including the function of bone-forming osteoblast cells. "These data improve our understanding of the gene networks important for osteoblast function," the study's authors say, "and demonstrates the ability of systems genetics to unravel gene networks involved in complex cellular processes."

Expression levels of the interleukin IL-22 can help predict response to vaccines targeting bovine tuberculosis, according to a PLOS Pathogens study. A team from Germany, the UK, and Canada found 668 differentially expressed genes when they compared gene expression on peripheral blood cells from vaccine-protected, vaccine-unprotected, or unvaccinated calves. In particular, they report, the efficacy of a Bacillus Calmette-Guérin vaccine produced from the Danish Mycobacterium bovis strain 1331 SSI appeared to be tied to the expression of IL-22. The results point to IL-22 as a "predictive biomarker that can be used in future experiments," researchers explain, "and also highlighted the role of T-cells producing this cytokine in protective immunity."

The Scan

Purnell Choppin Dies

Purnell Choppin, a virologist who led the Howard Hughes Medical Institute, has died at 91, according to the Washington Post.

Effectiveness May Decline, Data From Israel Suggests

The New York Times reports that new Israeli data suggests a decline in Pfizer-BioNTech SARS-CoV-2 vaccine effectiveness against Delta variant infection, though protection against severe disease remains high.

To See Future Risk

Slate looks into the use of polygenic risk scores in embryo screening.

PLOS Papers on Methicillin-Resistant Staphylococcus, Bone Marrow Smear Sequencing, More

In PLOS this week: genomic analysis of methicillin-resistant Staphylococcus pseudintermedius, archived bone marrow sequencing, and more.