This Week in PLOS

In PLOS Genetics, an international research group delves into the genetics of chronic pain. After using a heat test to quantify pain susceptibility in more than 2,500 TwinsUK project participants, investigators did exome sequencing on a few hundred women from the cohort's pain-sensitive and -insensitive extremes: 203 pain-sensitive or insensitive individuals from TwinsUK1 and 210 pain-prone or tolerant women from the study's second phase.

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In PLOS this week: GWAS links gene to noise-induced hearing loss in mice, population genetics of malaria parasites, and more.

Nautilus' Alexandra Ossola examines how Tay-Sachs disease jump-started the genetic disease testing field.

FASEB says guidelines proposed by the NIH to bolster research reproducibility are premature and don't take the full range of scientific studies into consideration.

Liquid biopsies and DNA tests may be able to tell physicians whether a cancer patient is relapsing, the New York Times reports.