This Week in PLOS

A team from the US, Russia, and Switzerland tracked down human-specific epigenetic marks in neurons from the prefrontal cortex, a brain region involved in higher order cognitive functions. As they report in PLOS Biology, the researchers assessed genome-wide histone H3 trimethyl-lysine 4, or H3K4me3, marks in prefrontal cortex samples from 11 humans, four chimpanzees, and three rhesus macaques. The search uncovered almost 500 sequences with human-specific H3K4me3 levels.

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