This Week in PLoS

Scientists have published work this week in PLoS Biology looking at genetic switches and gene expression related to cell fate. They used a "classic bistable memory module" to find transcription errors, using the lac operon in E. coli as a positive feedback loop. Using single cell analysis, they showed that when transcriptional fidelity decreases, the frequency of epigenetic switching from one state of expression to the other is increased.

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