Scientists from across Italy this week report on their Sanger and next-generation sequencing-based investigation of a series of 116 non-small-cell lung cancer samples. "Our findings suggest that a region in exon 19 is highly unstable in a large proportion of patients carrying EGFR deletions," the authors write in PLOS One.
Over in PLOS Genetics, a team led by investigators at Cancer Research UK discusses "the extent by which transcription of lncRNA loci is retained or lost across multiple evolutionary lineages." The team generated RNA-seq and ChIP-seq data to create catalogues of transcripts expressed in the adult liver of Mus musculus domesticus(C57BL/6J), Mus musculus castaneus, and Rattus norvegicus. The researchers used this to "estimate the rate of transcriptional turnover of lncRNAs and [investigate] the effects of their lineage-specific birth or death," finding that "lncRNA transcription showed considerably greater gain and loss during rodent evolution, compared with protein-coding genes," as they report.
In the same journal, the University of Texas MD Anderson Cancer Center's Abhinav Jain and Michelle Craig Barton comment on a new study from Memorial Sloan-Kettering Cancer Center's Carla Concepcion et al., which shows that miR-34 plays a redundant function in the p53 pathway. "Overall, the most striking result of p53 loss in vivo is early tumor predisposition in p53−/− mice, which lack genomic surveillance provided by p53-mediated regulation of cell cycle arrest, apoptosis, and senescence," Jain and Barton write in PLOS Genetics.