This Week in PLoS

In PLoS Biology this week, investigators at MD Anderson Cancer Center and their collaborators show that "p53 plays an active role in promoting differentiation of human embryonic stem cells and opposing self-renewal by regulation of specific target genes and microRNAs." Further, the team writes, "p53 activates expression of miR-34a and miR-145, which in turn repress stem cell factors OCT4, KLF4, LIN28A, and SOX2 and prevent backsliding to pluripotency." and This study "under

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The apple has traveled westward and eastward along the Silk Road, according to a new genetic analysis.

In Nature this week: GWAS data used to reposition drugs for psychiatric use, and more.

Genetic disease risk information doesn't always spur people to make healthy lifestyle changes, according to the Associated Press.

A University of California, San Diego-led team has used liquid biopsies to uncover possible treatments for patients with cancers of unknown primary.