This Week in PLoS

In PLoS Biology this week, investigators at MD Anderson Cancer Center and their collaborators show that "p53 plays an active role in promoting differentiation of human embryonic stem cells and opposing self-renewal by regulation of specific target genes and microRNAs." Further, the team writes, "p53 activates expression of miR-34a and miR-145, which in turn repress stem cell factors OCT4, KLF4, LIN28A, and SOX2 and prevent backsliding to pluripotency." and This study "under

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Researchers have sequenced the northern white rhinoceros to gauge whether it could be brought back from the edge of extinction, the New York Times reports.

Tufts University researchers found a role for miRNA in transmitting stress between generations, the Economist reports.

Bavaria expands its forensic genetic analyses to include DNA phenotyping, raising discrimination concerns.

In Science this week: gut microbiome influences liver cancer growth, spread; and more.