This Week in PLoS

In PLoS Genetics this week, McGill University's Brent Richards and his colleagues report on their analysis of data derived from 1,998 individuals they Sanger-sequenced at seven genes, which "provide guidance in the analysis and interpretation of the role of rare base-pair variation in the etiology of complex traits and diseases," the authors write.

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The US Food and Drug Administration has approved Alnylam's RNAi-based therapy Onpattro, according to Stat News.

Harvard Medical School's Seth Cassel and Cigall Kadoch argue in a Baltimore Sun op-ed that the recent TAILORx trial shows the potential of genomic-based medicine.

Researchers in the UK are working on using gene drives to control malaria-carrying mosquitoes, the Telegraph reports.

In PLOS this week: genetic architecture mediating gene expression, metabolomic patterns in multiple myeloma, and more.