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This Week in PLoS: Jan 28, 2009

A study published today in PLoS Biology looked at increased evolutionary rates in genes, and found, among alignments of 10,238 human genes to their orthologues in chimpanzee and macaque, exons evolving at a fast rate in humans have a tendency to contain clusters of AT-to-GC (weak-to-strong) biased substitutions. These exons are found in regions with increased male recombination rates and exhibit an increase in nonsynonymous substitutions relative to the genomic average, the authors write.

Computational biologists used the Joint Evolutionary Trees method on families of homologous sequences to provide proof of concept work that JET is a reliable method for detecting protein interactions. They applied the method to a database of 62 heterodimer, homodimer, and transient complexes and on 265 interfaces belonging to signal transduction proteins, enzymes, inhibitors, antibodies, antigens, and others. Their work was published in PLoS Computational Biology.

In PLoS Genetics, there's a paper studying the genetic changes among species of E. coli. Scientists re-annotated the genomes of 20 E. coli strains and one strain of E. fergusonii and found that within the approximately 18,000 families of orthologous genes, about 2,000 were common to all strains. Genome flux in E. coli is confined to a small number of conserved positions in the chromosome, they write, such that "overall, despite a very high gene flow, genes co-exist in an organized genome."

Finally, a paper in PLoS One used NMR metabolomic profiling to study the unexpected antileukemic effects of bezafibrate and medroxyprogesterone acetate on three acute myeloid leukemia cell lines. They found that the early changes in cells were less noticeable than the constitutive metabolic differences between cell types, suggesting that metabolic profiling is a good tool for drug discovery.

The Scan

Billions for Antivirals

The US is putting $3.2 billion toward a program to develop antivirals to treat COVID-19 in its early stages, the Wall Street Journal reports.

NFT of the Web

Tim Berners-Lee, who developed the World Wide Web, is auctioning its original source code as a non-fungible token, Reuters reports.

23andMe on the Nasdaq

23andMe's shares rose more than 20 percent following its merger with a special purpose acquisition company, as GenomeWeb has reported.

Science Papers Present GWAS of Brain Structure, System for Controlled Gene Transfer

In Science this week: genome-wide association study ties variants to white matter stricture in the brain, and more.