This Week in PLoS

This week in PLoS Genetics, an international team led by investigators at the National Human Genome Research Institute reports evidence to suggest that loss-of-function mutations in Atad5 — the human ortholog of yeast Elg1 — "are sufficient to cause genomic instability and tumorigenesis." The NHGRI-led team found that the heterozygous Atad5+/m mice they generated "displayed high levels of genomic instability in vivo," while Atad5+/m mouse embryonic fibroblasts showed "molecular defects in PCNA deubiquitination in response to DNA damage, as well as DNA

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The London School of Economics' Daniele Fanelli argues at the Proceedings of the National Academy of Sciences that the reproducibility crisis in science isn't as dire as some say.

A team of researchers in Portugal has examined the genomic basis for racing pigeons' athleticism and navigational skills, finding it's likely polygenic.

Wired reports that diagnostic firms continue to seek, post-Theranos, the ability to diagnose diseases from small amounts of blood.

In Science this week: analysis of DNA from ancient North Africans, and more.