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This week in PLoS Genetics, an international team led by investigators at the National Human Genome Research Institute reports evidence to suggest that loss-of-function mutations in Atad5 — the human ortholog of yeast Elg1 — "are sufficient to cause genomic instability and tumorigenesis." The NHGRI-led team found that the heterozygous Atad5+/m mice they generated "displayed high levels of genomic instability in vivo," while Atad5+/m mouse embryonic fibroblasts showed "molecular defects in PCNA deubiquitination in response to DNA damage, as well as DNA

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NPR reports the US Food and Drug Administration has approved a treatment for a genetic disorder that causes rapid aging.

Late-stage testing indicates the AstraZeneca and Oxford University SARS-CoV-2 vaccine can have up to 90 percent efficacy, the Associated Press reports.

ScienceInsider reports Nature Communications is reviewing a paper on mentorship following social media criticism arguing it is sexist.

In PLOS this week: method to account for sequencing errors in phylogenies, study of influenza A in Switzerland, and more.