This Week in PLoS

This week in PLoS Genetics, investigators at the University of Michigan describe the "pathogenic mechanism of the FIG4 mutation responsible for Charcot-Marie-Tooth disease CMT4J." In developing a mouse model of this severe form of Charcot-Marie-Tooth neuropathy "by expressing a Fig4-I41T cDNA transgene on the Fig4 null background," the team found that "FIG4-I41T is a hypomorphic allele encoding a protein that is unstable in vivo … suggesting that patients with CMT

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CNBC reports that Amazon invested in the startup Grail as it sees an opportunity for its cloud computing company in genomics.

Lawrence Krauss writes at Slate that science is needed for good public policy and should not be ignored.

Researchers are working on re-making the yeast genome from scratch, according to the Associated Press.

In Cell this week: functional profiling of Plasmodium genome, a self-inactivating rabies virus, and more.