This Week in PLoS

This week in PLoS Genetics, investigators at the University of Michigan describe the "pathogenic mechanism of the FIG4 mutation responsible for Charcot-Marie-Tooth disease CMT4J." In developing a mouse model of this severe form of Charcot-Marie-Tooth neuropathy "by expressing a Fig4-I41T cDNA transgene on the Fig4 null background," the team found that "FIG4-I41T is a hypomorphic allele encoding a protein that is unstable in vivo … suggesting that patients with CMT

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