This Week in PLoS

In PLoS Computational Biology this week, researchers in British Columbia led by Sohrab Shah report on a computational method they developed to detect novel gene fusions in cancer transcriptomes. The researchers say that their method, called deFuse, "considers all alignments and all possible locations for fusion boundaries" in contrast to others that only look for boundaries at the ends of exons.

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The US Food and Drug Administration has approved Alnylam's RNAi-based therapy Onpattro, according to Stat News.

Harvard Medical School's Seth Cassel and Cigall Kadoch argue in a Baltimore Sun op-ed that the recent TAILORx trial shows the potential of genomic-based medicine.

Researchers in the UK are working on using gene drives to control malaria-carrying mosquitoes, the Telegraph reports.

In PLOS this week: genetic architecture mediating gene expression, metabolomic patterns in multiple myeloma, and more.