This Week in PLoS

In PLoS One this week, investigators at Helicos BioSciences say that for RNA-seq analysis, "it is essential to understand how technical variation impacts the quality and interpretability of results, how potential errors could be introduced by the protocol, how the source of RNA affects transcript detection, and how all of these variations can impact the conclusions drawn." By running a variety of human RNA samples through fragmentation, fractionation, cDNA synthesis, and single- versus multiple-tag counting protocols, the Helicos team assessed the advantages and disadvantages of

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A fire at a Manchester hospital may have destroyed lab equipment and data, the Guardian reports.

Researchers generate a genetic database from skeletal remains from the 1845 Franklin Expedition to the Arctic, Live Science reports.

Researchers in China have begun another trial using CRISPR/Cas9 approaches in cancer patients, according to the Wall Street Journal.

In Science this week: human DNA found in sediments from archeological sites lacking bones, and more.