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In PLoS One this week, a research team led by investigators at the University of Maryland School of Medicine show that polymorphisms of CYP19A1, a gene that encodes aromatase, "are associated with survival among patients with cardiovascular disease in a sex-specific manner." In case-control studies, the Maryland-led team genotyped participants for six CYP19A1 SNPs. For one SNP in particular — -81371 C — the team observed a 78 percent increase in mortality for men with acute coronary syndrome, as compared with affected women. The authors say that theirs is the first "study ...

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