This Week in PLoS

In PLoS Genetics this week, researchers in France describe "alternative splicing at a NAGNAG acceptor site as a novel phenotype modifier." Upon their identification of a mild to asymptomatic phenotype in cystic fibrosis patients homozygous for the E831X mutation in CFTR, the team performed in silico analyses and determined that there is "an indel of a stop codon by alternative splicing at a NAGNAG acceptor site," which contributes to "proteome plasticity" and confers the ability to "remove a disease-causing UAG stop codon."

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The apple has traveled westward and eastward along the Silk Road, according to a new genetic analysis.

In Nature this week: GWAS data used to reposition drugs for psychiatric use, and more.

Genetic disease risk information doesn't always spur people to make healthy lifestyle changes, according to the Associated Press.

A University of California, San Diego-led team has used liquid biopsies to uncover possible treatments for patients with cancers of unknown primary.