In PLoS Genetics this week, a team of investigators led by researchers at the Washington University School of Medicine report that rs1868402, a SNP in the gene encoding the regulatory sub-unit of protein phosphatase B, is associated with cerebrospinal fluid ptau181 levels, and therefore "rate of decline in Alzheimer's disease." The team's "analyses suggest that genetic variants associated with CSF ptau181 levels may have a greater impact on rate of progression, while genetic variants such as APOE4, that are associated with CSF Aβ42 levels influence risk and onset but not the rate o