This Week in PLoS

Scientists publishing in PLoS Biology this week have used stable isotope labeling with amino acids in cell culture (SILAC) and subsequent mass spec to screen the human proteome for possible targets of γ-secretase and found a small number of new substrates, all of which are type I transmembrane proteins with diverse biological roles.

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An analysis of UK Biobank data finds hemochromatosis to be more prevalent than thought, according to the BBC.

An analysis finds that female biomedical researchers receive fewer prizes than male ones, and when they do win prizes, they are less prestigious.

Federal researchers tell the Los Angeles Times that the shutdown is causing missed research opportunities as they try to keep their experiments going.

In Nature this week: improved genomic analysis using a graph genome reference, tumor mutational burden could predict clinical response to immune checkpoint inhibitors, and more.