In a paper published online in advance in Nucleic Acids Research this week, investigators at Sloan-Kettering and Weill Cornell Medical College show that the activity of Nam8, a yeast U1 snRNP component that "collaborates with Mer1 to promote splicing of essential meiotic mRNAs," is weakened by "mutations in the putative RNA binding site of the RRM2 and RRM3 domains." More specifically, the team says SPO22 and PCH2 are targets of Nam8-dependent meiotic splicing; the researchers als

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Microsoft co-founder Paul Allen also contributed to brain research, NPR reports.

The New York Times reports on the shifting interpretations of what some genetic variants mean over time.

In Cell this week: investigation of metastatic tumor evolution, more than 16,000 genetic variants introduced into the budding yeast model organism, and more.

MIT's Technology Review reports on Genentech's pursuit of personalized cancer vaccines.