In the online edition of Nucleic Acids Research, investigators from the US and Korea outlined a computational strategy for dialing down off-target interactions identified when doing loss-of-function screens with small interfering RNAs. The "Deconvolution Analysis of RNAi screening data," or DecoRNAi, method can automatically assess and diminish rates of off-target effects, according to the study's authors, who validated the strategy using data from five siRNA screens.

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