In an advance online article published in Nucleic Acids Research this week, a trio of researchers at Harvard Medical School describes improved and complete enrichment, co-amplification at lower denaturation temperature PCR — or ice-COLD-PCR — which they say "enables rapid amplification and robust enrichment for low-abundance unknown DNA mutations." The team tested the efficacy of ice-COLD-PCR by enriching regions of TP53 in serially diluted mutant and wild-type DNA mixtures.

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Microsoft co-founder Paul Allen also contributed to brain research, NPR reports.

The New York Times reports on the shifting interpretations of what some genetic variants mean over time.

MIT's Technology Review reports on Genentech's pursuit of personalized cancer vaccines.

In Cell this week: investigation of metastatic tumor evolution, more than 16,000 genetic variants introduced into the budding yeast model organism, and more.