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In a Nucleic Acids Research paper published online in advance this week, researchers show that different DNA methyltransferase domains "are responsible for targeting DNA methylation to specific regions of the genome," which may be associated with histone modifications. First, the team created HEK 293T cells transfected with 13 DNMTs. They then assessed methylation changes induced be each DNMT.

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In Nucleic Acids Research this week: the Aging Atlas database, a database of human metagenome-related metadata, and more.