A public-private team including investigators from SomaGenics, the University of California, San Francisco, Integrated DNA Technologies, and Stanford University School of Medicine shows in a paper published online in advance in Nucleic Acids Research this week that certain short shRNAs — or sshRNAs, which are "designated as L-type or R-type according to whether the loop is positioned 3′ or 5′ to the guide sequence, respectively" — require loop cleavage for optimum activity.

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Researchers hope to tease out the signature effects that different carcinogens leave on the genome to determine their contributions to disease, Mosaic reports.

The Wall Street Journal looks into the cost of new gene therapies.

An Imperial College London-led team reports that it was able to use a gene drive to control a population of lab mosquitos.

In PNAS this week: genomic effects of silver fox domestication, limited effect of mitochondrial mutations on aging in fruit flies, and more.