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A public-private team including investigators from SomaGenics, the University of California, San Francisco, Integrated DNA Technologies, and Stanford University School of Medicine shows in a paper published online in advance in Nucleic Acids Research this week that certain short shRNAs — or sshRNAs, which are "designated as L-type or R-type according to whether the loop is positioned 3′ or 5′ to the guide sequence, respectively" — require loop cleavage for optimum activity.

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In a letter, about two dozen researchers criticize the World Health Organization investigation into the origins of SARS-CoV-2 and call for a new inquiry, the Wall Street Journal reports.

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