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This Week in Nucleic Acids Research: May 16, 2012

In a paper published online in advance in Nucleic Acids Research this week, Jiri Vohradsky from the Czech Republic Academy of Sciences' Institute of Microbiology presents a procedure for the stochastic simulation of gene expression, which he used to investigate the expression dynamics of yeast cyclins and cyclin-dependent kinases. In his simulations, Vohradsky found that the "level of influence of individual regulators in control of the regulated genes is defined," he writes.

And researchers at the US Department of Defense Biotechnology High Performance Computing Software Applications Institute present an approach to reduce allelic bias in RNA-seq read-mapping based on the "construction of an enhanced reference genome that includes the alternative alleles at known polymorphic loci." In a Nucleic Acids Research paper published online in advance the team this week shows that "mapping to this enhanced reference reduced the read-mapping biases, leading to more reliable estimates of ASE [allele-specific expression]."

The Scan

Could Cost Billions

NBC News reports that the new Alzheimer's disease drug from Biogen could cost Medicare in the US billions of dollars.

Not Quite Sent

The Biden Administration likely won't meet its goal of sending 80 million SARS-CoV-2 vaccine doses abroad by the end of the month, according to the Washington Post.

DTC Regulation Proposals

A new report calls on UK policymakers to review direct-to-consumer genetic testing regulations, the Independent reports.

PNAS Papers on Mosquito MicroRNAs, Acute Kidney Injury, Trichothiodystrophy

In PNAS this week: microRNAs involved in Aedes aegypti reproduction, proximal tubule cell response to kidney injury, and more.