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This Week in Nucleic Acids Research: Nov 2, 2011

In a paper published online in advance in Nucleic Acids Research this week, researchers at Illumina describe their approach to "make individual or pools of purified 5' biotin-functionalized oligonucleotides," which they say is "based on 5'-hexa-His phase tag purification, followed by exchange of the hexa-His tag for a functional group using reversible reaction chemistry." The Illumina team reports cases in which it prepared "5'-biotin, 95-mer, oligonucleotide pools of [greater than] 40K complexity at micromole scale," and discusses the potential of its approach for use in other applications.

For its database issue, Nucleic Acids Research this week published three papers online in advance from researchers who present "a comprehensive online resource for fission yeast," an allele frequency resource, and "a repository of experimentally characterized prokaryotic glycoproteins." The University of Cambridge's Valerie Wood and her colleagues present PomBase, Yale University School of Medicine's Haseena Rajeevan et al. describe ALFRED, and Aadil Bhat and colleagues at India's Council of Scientific and Industrial Research present ProGlycProt, respectively.

The Scan

Two J&J Doses

Johnson & Johnson says two doses of its SARS-CoV-2 vaccine provides increased protection against symptomatic COVID-19, CNN reports.

Pfizer-BioNTech Vaccine Response in Kids

The Pfizer-BioNTech SARS-CoV-2 vaccine in a lower-dose format appears to generate an immune response among children, according to the Washington Post.

Chicken Changes to Prevent Disease

The Guardian writes that researchers are looking at gene editing chickens to help prevent future pandemics.

PNAS Papers on Siberian Dog Ancestry, Insect Reproduction, Hippocampal Neurogenesis

In PNAS this week: ancestry and admixture among Siberian dogs, hormone role in fruit fly reproduction, and more.