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This Week in Nucleic Acids Research: Nov 2, 2011

In a paper published online in advance in Nucleic Acids Research this week, researchers at Illumina describe their approach to "make individual or pools of purified 5' biotin-functionalized oligonucleotides," which they say is "based on 5'-hexa-His phase tag purification, followed by exchange of the hexa-His tag for a functional group using reversible reaction chemistry." The Illumina team reports cases in which it prepared "5'-biotin, 95-mer, oligonucleotide pools of [greater than] 40K complexity at micromole scale," and discusses the potential of its approach for use in other applications.

For its database issue, Nucleic Acids Research this week published three papers online in advance from researchers who present "a comprehensive online resource for fission yeast," an allele frequency resource, and "a repository of experimentally characterized prokaryotic glycoproteins." The University of Cambridge's Valerie Wood and her colleagues present PomBase, Yale University School of Medicine's Haseena Rajeevan et al. describe ALFRED, and Aadil Bhat and colleagues at India's Council of Scientific and Industrial Research present ProGlycProt, respectively.

The Scan

Study Reveals New Details About Genetics of Major Cause of Female Infertility

Researchers in Nature Medicine conducted a whole-exome sequencing study of mote than a thousand patients with premature ovarian insufficiency.

Circulating Tumor DNA Shows Potential as Biomarker in Rare Childhood Cancer

A study in the Journal of Clinical Oncology has found that circulating tumor DNA levels in rhabdomyosarcoma may serve as a biomarker for prognosis.

Study Recommends Cancer Screening for Dogs Beginning Age Seven, Depending on Breed

PetDx researchers report in PLOS One that annual cancer screening for dogs should begin by age seven.

White-Tailed Deer Harbor SARS-CoV-2 Variants No Longer Infecting Humans, Study Finds

A new study in PNAS has found that white-tailed deer could act as a reservoir of SARS-CoV-2 variants no longer found among humans.