Researchers in Madrid report that the Streptococcus pneuomoniae genome is "organized in topology-reacting gene clusters" that respond to DNA supercoiling in Nucleic Acids Research this week. The team writes that down-regulated genomic clusters are "flanked by 11-40 kb AT-rich zones that might have a putative structural function" and suggest that DNA supercoiling "controls gene expression superimposed on other kinds of more specific regulatory mechanisms."

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