Researchers in Madrid report that the Streptococcus pneuomoniae genome is "organized in topology-reacting gene clusters" that respond to DNA supercoiling in Nucleic Acids Research this week. The team writes that down-regulated genomic clusters are "flanked by 11-40 kb AT-rich zones that might have a putative structural function" and suggest that DNA supercoiling "controls gene expression superimposed on other kinds of more specific regulatory mechanisms."

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An artificial intelligence-based analysis suggests a third group of ancient hominins likely interbred with human ancestors, according to Popular Mechanics.

In Science this week: reduction in bee phylogenetic diversity, and more.

The New York Times Magazine looks into paleogenomics and how it is revising what's know about human history, but also possibly ignoring lessons learned by archaeologists.

The Economist reports on Synthorx's efforts to use expanded DNA bases they generated to develop a new cancer drug.