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This Week in Nature Genetics

In Nature Genetics this week, two papers highlight some interesting genomics handiwork. In one, Howard Hughes researchers at the University of Utah have devised a cheap, efficient method for creating and then breeding large-scale, genome-wide deletions and duplications in mice. They hope to be able to use the mutated mice for visualizing the effect that translocations within noncoding regions have on the development of human cancers.

Another paper reports on the sequencing of the genomes of two species of the parasite that causes Leishmaniasis, a disease that affects two million people each year. Remarkably, only about 200 genes are different between the two newly sequenced species, Leishmania infantum and Leishmania braziliensis, and the published genome of Leishmania major. This small window of variation will hopefully give geneticists a way to effectively pinpoint where to start searching for improved drug targets.

Several other studies have found mutations on specific genes that confer susceptibility to celiac disease, Crohn's disease, type 1 diabetes, and ER–positive breast cancer.

The Scan

Fertility Fraud Found

Consumer genetic testing has uncovered cases of fertility fraud that are leading to lawsuits, according to USA Today.

Ties Between Vigorous Exercise, ALS in Genetically At-Risk People

Regular strenuous exercise could contribute to motor neuron disease development among those already at genetic risk, Sky News reports.

Test Warning

The Guardian writes that the US regulators have warned against using a rapid COVID-19 test that is a key part of mass testing in the UK.

Science Papers Examine Feedback Mechanism Affecting Xist, Continuous Health Monitoring for Precision Medicine

In Science this week: analysis of cis confinement of the X-inactive specific transcript, and more.