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This Week in Nature Genetics

In Nature Genetics this week, two papers highlight some interesting genomics handiwork. In one, Howard Hughes researchers at the University of Utah have devised a cheap, efficient method for creating and then breeding large-scale, genome-wide deletions and duplications in mice. They hope to be able to use the mutated mice for visualizing the effect that translocations within noncoding regions have on the development of human cancers.

Another paper reports on the sequencing of the genomes of two species of the parasite that causes Leishmaniasis, a disease that affects two million people each year. Remarkably, only about 200 genes are different between the two newly sequenced species, Leishmania infantum and Leishmania braziliensis, and the published genome of Leishmania major. This small window of variation will hopefully give geneticists a way to effectively pinpoint where to start searching for improved drug targets.

Several other studies have found mutations on specific genes that confer susceptibility to celiac disease, Crohn's disease, type 1 diabetes, and ER–positive breast cancer.

The Scan

Alzheimer's Risk Gene Among Women

CNN reports that researchers have found that variants in MGMT contribute to Alzheimer's disease risk among women but not men.

Still Hanging Around

The Guardian writes that persistent pockets of SARS-CoV-2 in the body could contribute to long COVID.

Through a Little Spit

Enteric viruses like norovirus may also be transmitted through saliva, not just the fecal-oral route, according to New Scientist.

Nature Papers Present Method to Detect Full Transcriptome, Viruses Infecting Asgard Archaea, More

In Nature this week: VASA-seq approach to detect full transcriptome, analysis of viruses infecting Asgard archaea, and more.