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This Week in Nature: Nov 20, 2008

The extinct woolly mammoth genome, Mammuthus primigenius, has been (mostly) sequenced, and it's gotten a lot of buzz from both bloggers and news organizations alike. Sequencing about 70 percent of the 4 billion bases showed that DNA substitution rate seems to be smaller than in humans and identified several protein-coding positions that are unique to the mammoth compared with 50 other vertebrate species. At Dechronization, Susan Perkins thinks the work has created a new 'omics, "'Museomics' where natural history specimens, ancient DNA technology and pyrosequencing combine." The NYT reports on the case, looking at the actual possibility of recreating a live creature from an extinct DNA sequence "for as little as $10 million."

A special section on Darwin celebrates the 150th anniversary of the publication of The Origin of Species and his 200th birthday next year. A slew of articles dig in, including an editorial on what evolutionary theory could allow scientists to create in the future, an article tying evolutionary study and sys bio together, and a slideshow of eyes from different living organisms. Go here to see the site that Nature News has launched to get ready for Darwin's 200th birthday.

Erika Check Hayden checks in on the potential future widespread use of SNP chips to screen embryos in IVF. While they can currently screen for single-gene diseases, chips for screening an embryo's risk for adult-onset diseases like diabetes and obesity is dubious as of now. Says Daniel MacArthur at Genetic Future: "With hundreds of different common variants (and untold numbers of rare variants) underlying common diseases, no embryo will be completely free of genetic risk factors."

In early online publications, scientists looked at conservation of Y-linked genes among the 12 sequenced Drosophila genomes, finding that only a quarter of these genes are Y-linked in all species. They also found that the rate of gene gain in the Drosophila Y chromosomes is 10.9 times higher than the rate of gene loss, "indicating a clear tendency of the Y chromosomes to increase in gene content," the authors write. "In contrast with the mammalian Y chromosome, gene gains have a prominent role in the evolution of the Drosophila Y chromosome."

 

The Scan

Gone, But Now Reconstructed SARS-CoV-2 Genomes

In a preprint, a researcher describes his recovery of viral sequences that had been removed from a common database.

Rare Heart Inflammation Warning

The Food and Drug Administration is adding a warning about links between a rare inflammatory heart condition and two SARS-CoV-2 vaccines, Reuters reports.

Sandwich Sampling

The New York Times sent tuna sandwiches for PCR analysis.

Nature Papers Describe Gut Viruses, New Format for Storing Quantitative Genomic Data, More

In Nature this week: catalog of DNA viruses of the human gut microbiome, new dense depth data dump format to store quantitative genomic data, and more.