Two studies this week look at large-scale structural variation in schizophrenia. The International Schizophrenia Consortium used microarrays to survey rare CNVs in 3,391 schizophrenics and found that these CNVs increased 1.15-fold. Associations with schizophrenia were also found for large deletions on chromosome 15q13.3 and 1q21.1. Another study from DeCode examined 66 de novo CNVs, finding three deletions at 1q21.1, 15q11.2, and 15q13.3. "Despite selection against the disease, according to this new idea, schizophrenia continues to appear because it is driven by a spate of new mutations that occur all the time in the population," says a New York Times article.
Also in early online publication, two teams have looked for the first time at how miRNAs affect protein expression on a genome-wide scale. Dave Bartel's lab measured protein expression using quantitative mass spectrometry after introducing microRNAs into cultured cells and after deleting mir-223 in mouse neutrophils. He found hundreds of proteins were repressed, but each to a small degree. Another study out of Berlin's Max Delbrück Center for Molecular Medicine showed the same thing. A news article follows up on these first large-scale analyses.
Max Planck researchers have made iPS cells from adult neural stem cells using only two reprogramming factors instead of the usual four. "These two-factor iPS cells are similar to embryonic stem cells at the molecular level, contribute to development of the germ line, and form chimaeras," they write in the abstract.
NPG officially launched the first phase of its Manuscript Deposition Service, says Open Access News. The free service will help authors meet public access mandates by depositing authors' accepted manuscripts with PubMed Central and UK PubMed Central.