This Week in Nature

In early online publication University College London researchers present findings on partial agonists, and how fully elucidating their function could make for better drug design. They say that in the case of ligand-activated ion channels, two members of the nicotinic family in particular, partial agonists cause a flipping conformational change in the channel that happens while the channel is still shut.

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The apple has traveled westward and eastward along the Silk Road, according to a new genetic analysis.

In Nature this week: GWAS data used to reposition drugs for psychiatric use, and more.

Genetic disease risk information doesn't always spur people to make healthy lifestyle changes, according to the Associated Press.

A University of California, San Diego-led team has used liquid biopsies to uncover possible treatments for patients with cancers of unknown primary.