An editorial discusses what should be done for Europe to have a free exchange of science. The “green paper” issued by the European Commission identifies the issues plaguing European research, such as incompatible inter-country regulations and a lack of funding sources, and asks for suggestion to remedy those problems, but the editorial says that “the commission does not have the clout to implement such reforms on its own.”
The cover of this week’s issue features cancer genomics and the work of Charles Mullighan and his colleagues. Using SNP arrays, they looked for genetic lesions in pediatric acute lymphoblastic leukemia cells. In their genome-wide search, the researchers found that in one copy of chromosome 9 a small portion was missing — the part belonging to the PAX5 gene. This study, says the related News and Views, will affect large-scale efforts to characterize the cancer genome as well as underscore the importance of genomic copy number.
Another article introduces an epistatic miniarray profile of 743 Saccharomyces cerevisiae genes. Led by Sean Collins, the researchers created the map by evaluating the pair-wise genetic interactions of these genes that were involved in chromosomal maintenance. The map showed that the genes could be separated into two classes based on whether the proteins perform a similar function.