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This Week in Nature: May 15, 2008

Nature has a special insight section on regenerative medicine that explores "the promises and challenges of the next era of regenerative medicine — and how to use the information gained from the study of model organisms and cell culture to eventually heal ourselves." A series of articles looks at new disease models to study molecular pathways, studying self-renewal in hematopoietic stem cells, stem cell therapy in heart disease, applying single-cell imaging approaches, and others.

A paper out of Penn State describes mapping the nucleosome locations across the Drosophila genome and comparing it to that of Saccharomyces cerevisiae. Researchers conclude that how the transcription initiation machinery engages the +1 nucleosome "seems to be fundamentally different across major eukaryotic lines."
 
Researchers at Imperial College London have done a large-scale study to look at the variation in metabolism across four different populations. Using NMR spectroscopy to find metabolites linked to blood pressure, they found that among the 4,630 participants, different patterns emerged from East Asian vs. Western, Chinese vs. Japanese, and sub-groups with differences in dietary vegetable/animal protein. They hope to use the data to find new biomarkers related to heart disease and stroke.

Finally, a short article lists questions one should ask during a postdoc interview, including those related to mentorship, authorship, lab alumni, productivity measures, and more.

 

The Scan

Billions for Antivirals

The US is putting $3.2 billion toward a program to develop antivirals to treat COVID-19 in its early stages, the Wall Street Journal reports.

NFT of the Web

Tim Berners-Lee, who developed the World Wide Web, is auctioning its original source code as a non-fungible token, Reuters reports.

23andMe on the Nasdaq

23andMe's shares rose more than 20 percent following its merger with a special purpose acquisition company, as GenomeWeb has reported.

Science Papers Present GWAS of Brain Structure, System for Controlled Gene Transfer

In Science this week: genome-wide association study ties variants to white matter stricture in the brain, and more.