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A news story examines the fate of using surrogate biomarkers in clinical trials. So far, reliance on markers that don't necessarily correlate with a disease itself has helped "fast-track" many drugs through the FDA approval process. Surprising findings about drugs, like GSK's Avandia, have people questioning dependence on these kinds of markers.

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Nature News writes that additional details about the UK plan for an agency to support high-risk, high-reward science are needed.

The New York Times reports that the US Food and Drug Administration has authorized Johnson & Johnson's SARS-CoV-2 vaccine.

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In PLOS this week: analysis of Plasmodium population structure, qPCR assay to diagnose scabies, and more.