A news feature in this week’s Nature reviews genome-wide association studies. Issues include just how reproducible and valid the data from these studies actually are, as well as how productive pooling of resources and sharing data in worldwide data repositories will be.
Two papers out of Brookhaven National Laboratory and Chad Mirkin's Northwestern lab feature successful assembly techniques of three-dimensional gold nanoparticles using DNA. By attaching complementary strands to the particles, they carry the particles with them when they hybridize, creating macromolecular structures. "The ultimate dream is the creation of a DNA tool-kit that will make possible the self-assembly of nearly any material reliably at the nanoscale," says a News and Views article.
Researchers at the Weizmann Institute of Science have created a computational model to describe the thermodymanics of the expression patterns among cis-regulatory elements and their bound transcription factors. They report that when they applied this model to the segmentation gene network of D. melanogaster, they found that it predicts expression patterns of cis-regulatory elements "with remarkable accuracy."