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This Week in Nature: Nov 13, 2014

In Nature Genetics this week, an international team of researchers reports on the discovery of a genetic variant associated with a decreased risk of contracting typhoid fever. By conducting a genome-wide association study of 432 individuals with blood culture-confirmed typhoid fever and roughly 2,000 controls, they identified a genetic variant at HLA-DRB1 that confers almost five-fold greater protection from the disease than the alternate variants of the same gene. GenomeWeb Daily News has more on this study here.

Also in Nature Genetics, a team of Swedish scientists describe a methodology for uncovering associations between somatic mutations in regulatory DNA and changes in gene expression levels in a pan-cancer setting. By mapping and analyzing somatic mutations in 505 tumor genomes across 14 cancer types, they found that mutations in TERT regulatory DNA exhibit an remarkably strong and genome-wide significant association with altered promoter activity. The strength of this association, however, was variable and strongest in copy-number stable cancers.

The Scan

Steps for Quick Review

The US Food and Drug Administration is preparing for the quick review of drugs and vaccines for the Omicron variant, according to the Wall Street Journal.

Moving Away From Using Term 'Race'

A new analysis finds that geneticists are using the term "race" in their papers less than in years past, as Science reports.

Point of the Program

The Guardian writes that some scientists have called the design of a UK newborn sequencing program into question.

Science Papers Present Multi-Omic Analysis of Lung Cells, Regulation of Cardiomyocyte Proliferation

In Science this week: a multi-omic analysis of lung cells focuses on RIT1-regulated pathways, and more.