This Week in Nature

In Nature Genetics this week, an international team of researchers reports on the discovery of a genetic variant associated with a decreased risk of contracting typhoid fever. By conducting a genome-wide association study of 432 individuals with blood culture-confirmed typhoid fever and roughly 2,000 controls, they identified a genetic variant at HLA-DRB1 that confers almost five-fold greater protection from the disease than the alternate variants of the same gene.

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