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This Week in Nature: Nov 13, 2014

In Nature Genetics this week, an international team of researchers reports on the discovery of a genetic variant associated with a decreased risk of contracting typhoid fever. By conducting a genome-wide association study of 432 individuals with blood culture-confirmed typhoid fever and roughly 2,000 controls, they identified a genetic variant at HLA-DRB1 that confers almost five-fold greater protection from the disease than the alternate variants of the same gene. GenomeWeb Daily News has more on this study here.

Also in Nature Genetics, a team of Swedish scientists describe a methodology for uncovering associations between somatic mutations in regulatory DNA and changes in gene expression levels in a pan-cancer setting. By mapping and analyzing somatic mutations in 505 tumor genomes across 14 cancer types, they found that mutations in TERT regulatory DNA exhibit an remarkably strong and genome-wide significant association with altered promoter activity. The strength of this association, however, was variable and strongest in copy-number stable cancers.

The Scan

Call to Look Again

More than a dozen researchers penned a letter in Science saying a previous investigation into the origin of SARS-CoV-2 did not give theories equal consideration.

Not Always Trusted

In a new poll, slightly more than half of US adults have a great deal or quite a lot of trust in the Centers for Disease Control and Prevention, the Hill reports.

Identified Decades Later

A genetic genealogy approach has identified "Christy Crystal Creek," the New York Times reports.

Science Papers Report on Splicing Enhancer, Point of Care Test for Sexual Transmitted Disease

In Science this week: a novel RNA structural element that acts as a splicing enhancer, and more.