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This Week in Nature: Sep 26, 2014

In Nature Genetics this week, a team from the Chinese Academy of Fishery Sciences reports the genome sequence of the common carp, Cyprinus carpio, which is the world's most farmed species of fish. The researchers sequenced the genomes of 33 fish from four wild populations and six domestic strains. When comparing two common varieties, they found 894 differentially expressed genes, many of which are involved in scale development and pigmentation. This work is expected to provide information of economically important traits and help breeders improve farmed carp. GenomeWeb Daily News has more on the carp genome here.

And in Nature Methods, a group from the French National Center for Scientific Research describe a new method for 3D genome reconstruction using chromosomal contacts. A key challenge in chromosome conformation capture experiments is the reconstruction of spatial distances and three-dimensional genome structures from observed contacts between genomic loci. To address this, the investigators developed a two-step algorithm that avoids convergence issues, deals with limited or noisy contact maps, and is faster than existing methods.

The Scan

Genetic Ancestry of South America's Indigenous Mapuche Traced

Researchers in Current Biology analyzed genome-wide data from more than five dozen Mapuche individuals to better understand their genetic history.

Study Finds Variants Linked to Diverticular Disease, Presents Polygenic Score

A new study in Cell Genomics reports on more than 150 genetic variants associated with risk of diverticular disease.

Mild, Severe Psoriasis Marked by Different Molecular Features, Spatial Transcriptomic Analysis Finds

A spatial transcriptomics paper in Science Immunology finds differences in cell and signaling pathway activity between mild and severe psoriasis.

ChatGPT Does As Well As Humans Answering Genetics Questions, Study Finds

Researchers in the European Journal of Human Genetics had ChatGPT answer genetics-related questions, finding it was about 68 percent accurate, but sometimes gave different answers to the same question.