This Week in Nature

In Nature this week, a Boston-based team of researchers report on the use of the CRISPR/Cas9 technology to rapidly generate a cancer model in vivo in wild-type mice. Specifically, they used the approach to mutate the tumor-suppressor genes Pten and p53, resulting in mice with liver tumors that mimicked those caused when the genes are deleted using an existing technology.

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The US Food and Drug Administration has approved Alnylam's RNAi-based therapy Onpattro, according to Stat News.

Harvard Medical School's Seth Cassel and Cigall Kadoch argue in a Baltimore Sun op-ed that the recent TAILORx trial shows the potential of genomic-based medicine.

Researchers in the UK are working on using gene drives to control malaria-carrying mosquitoes, the Telegraph reports.

In PLOS this week: genetic architecture mediating gene expression, metabolomic patterns in multiple myeloma, and more.