This Week in Nature

In Nature Biotechnology this week, Massachusetts General Hospital researchers report on a technique for obtaining greater nuclease specificity with the gene-editing tool CRISPR. CRISPR works when Cas9 nucleases, directed by guide RNAs, cause double-strand breaks in specific DNA sequences. However, these nucleases can cause mutations at sites that differ by as many as five nucleotides from their intended targets.

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The Wall Street Journal reports Human Longevity's valuation has dropped by 80 percent.

The New York Times and ProPublica say that many physicians fail to disclose their financial ties when publishing in medical journals.

Science reports that the US National Cancer Institute is cutting its operating budget by 5 percent.

In PLOS this week: similar variants seen in bullbogs, people with Robinow syndrome; ApoE genotypes in African-American, Puerto Rican populations; and more.