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This Week in Nature: Nov 1, 2007

In news, the Boston-based Autism Consortium released raw genotype data from 4,250 individuals — including people with autism, their parents and their siblings. Collaborating lead investigators Aravinda Chakravarti of Johns Hopkins and Mark Daly of the Autism Consortium hope to identify key variants over the next several months.

Scientists at the Scottish Crop Research Institute report functional analyses of RXLR and EER, two motifs that are present in translocated oomycete effector proteins, which help these "water molds" transmit disease. By substituting these motifs with alanine residues, they confirmed that RXLR and EER are required for translocation. Further bioinformatic analysis identified 425 potential genes encoding secreted RXLR-EER class proteins in the Phytophthora infestans genome.

UNC researchers used a loss-of-function approach to demonstrate that the mouse histone demethylase JHDM2A (JmjC-domain-containing histone demethylase 2A) is essential for spermatogenesis. Their research showed that JHDM2A directly binds to and controls the expression of transition nuclear protein 1 (Tnp1) and protamine 1 (Prm1) genes in mice, which help package sperm chromatin.

The Scan

Gone, But Now Reconstructed SARS-CoV-2 Genomes

In a preprint, a researcher describes his recovery of viral sequences that had been removed from a common database.

Rare Heart Inflammation Warning

The Food and Drug Administration is adding a warning about links between a rare inflammatory heart condition and two SARS-CoV-2 vaccines, Reuters reports.

Sandwich Sampling

The New York Times sent tuna sandwiches for PCR analysis.

Nature Papers Describe Gut Viruses, New Format for Storing Quantitative Genomic Data, More

In Nature this week: catalog of DNA viruses of the human gut microbiome, new dense depth data dump format to store quantitative genomic data, and more.