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This Week in Nature: Dec 19, 2013

In Nature this week, a team led by Max Planck Institute researchers report on the sequencing of the genome of a Neanderthal woman from Denisova Cave in the Altai Mountains of Siberia. The DNA was obtained from a bone of an adult female who is thought to be about 50,000 years old. The scientists' analysis indicated that woman’s parents were closely related — possibly half-siblings or an uncle and niece — and that such mating among close relatives was not uncommon among her recent ancestors. Comparison of the genomic data with a low-coverage genome from a Neanderthal from the Caucasus region and with 25 present-day human genomes reveals several low-level gene-flow events among Neanderthals, Denisovans, and early modern humans, and suggest that several hominin groups frequently interbred during the Late Pleistocene, between about 12,000 years and 126,000 years ago.

Also in Nature, University of Pittsburgh researchers publish data showing that the deadly North American eastern equine encephalitis virus — an RNA virus spread by mosquitos — uses a microRNA to suppress viral replication inside host immune cells, thereby inhibiting immunity. The discovery gives clues as to why the virus is so lethal. "We propose that RNA viruses can adapt to use antiviral properties of vertebrate miRNAs to limit replication in particular cell types and that this restriction can lead to exacerbation of disease severity," the researchers add.

The Scan

Guidelines for Ancient DNA Work

More than two dozen researchers have developed new ethical guidelines for conducting ancient DNA research, which they present in Nature.

And Cleared

A UK regulator has cleared former UK Prime Minister David Cameron in concerns he should have registered as a consultant-lobbyist for his work with Illumina, according to the Financial Times.

Suit Over Allegations

The Boston Globe reports that David Sabatini, who was placed on leave from MIT after allegations of sexual harassment, is suing his accuser, the Whitehead Institute, and the institute's director.

Nature Papers on Esophageal Cancer, Origin of Modern Horses, Exome Sequencing of UK Biobank Participants

In Nature this week: genetic and environmental influences of esophageal cancer, domestic horse origin traced to Western Eurasian steppes, and more.