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This Week in Nature: Aug 16, 2013

In Nature Genetics this week, researchers from the cross-disorder group of the Psychiatric Genomics Consortium publish the results of a genome-wide SNP study that identified a genetic relationship between five psychiatric disorders. Using genotype data from the consortium’s databases in schizophrenia, bipolar disorder, major depressive disorder, autism spectrum disorders, and attention-deficit/hyperactivity disorder, they applied univariate and bivariate methods to estimate genetic variation within and covariation between the disorders. The team found high genetic correlation between schizophrenia and bipolar disorder; moderate correlation between schizophrenia and major depressive disorder, bipolar disorder and major depressive disorder, and ADHD and major depressive disorder; and low correlation between schizophrenia and ASD. "This empirical evidence of shared genetic etiology for psychiatric disorders can inform nosology and encourages the investigation of common pathophysiologies for related disorders," the researchers note.

Meanwhile, in Nature Methods, a group from Harvard University and the Massachusetts Institute of Technology published a method for fluorescence in situ identification of individual mRNA molecules. The method allows for quantitative and accurate measurement, in single cells, of allele-specific transcripts that differ by only a few nucleotides, the researchers say. Using a combination of allele-specific and non–allele-specific probe libraries, the investigators were able to achieve greater than 95 percent detection accuracy.

The Scan

Gap in COVAX Doses

BBC News reports that COVAX is experiencing a vaccine shortfall, as the Serum Institute of India has paused exports.

Sanofi, GSK Report Promising Results

The Wall Street Journal reports that the candidate SARS-CoV-2 vaccine from Sanofi and GlaxoSmithKline has had encouraging early results.

Influence of Luck

The New York Times examines how the US avoided variant-fueled increases in COVID-19 cases.

PLOS Papers on Retina GWAS, Hantaan Virus, COVID-19 Phenome-Wide Association Study

In PLOS this week: genome-wide association study of retinal morphology, analysis of hantaan virus found in a mouse, and more.