This Week in Nature

Researchers from Japan and the US did whole-exome sequencing on tumor and matched normal samples from 13 individuals with juvenile myelomonocytic leukemia in their quest to find informative mutations in the pediatric leukemia — work that they describe in Nature Genetics.

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The US Food and Drug Administration has approved Alnylam's RNAi-based therapy Onpattro, according to Stat News.

Harvard Medical School's Seth Cassel and Cigall Kadoch argue in a Baltimore Sun op-ed that the recent TAILORx trial shows the potential of genomic-based medicine.

Researchers in the UK are working on using gene drives to control malaria-carrying mosquitoes, the Telegraph reports.

In PLOS this week: genetic architecture mediating gene expression, metabolomic patterns in multiple myeloma, and more.