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This Week in Nature: Dec 21, 2012

In Nature this week, University of California, Berkeley, researchers publish the draft genomes of two annelids — a freshwater leech and a marine polychaete — and one mollusk — the owl limpet — providing new insights into the evolution of bilateral symmetry. By comparing these genomes with those of other animals, the team identified some of the genetic changes that gave rise to bilaterians.

Our sister publication GenomeWeb Daily News has more on this study here.

Meanwhile, in Nature Genetics, Chinese scientists report on their whole-genome sequencing of 34 giant pandas and combined the findings with data from the previously deep-sequenced panda genome to reconstruct a continuous demographic history of pandas from their origin to the present day. They identified two population expansions, two bottlenecks, and two divergences, and conclude that human activities and not global climate changes have driven recent population divergence and decline.

GenomeWeb Daily News also covers this paper here.

The Scan

Sick Newborns Selected for WGS With Automated Pipeline

Researchers successfully prioritized infants with potential Mendelian conditions for whole-genome sequencing or rapid whole-genome sequencing, as they report in Genome Medicine.

Acne-Linked Loci Found Through GWAS Meta-Analysis

Researchers in the European Journal of Human Genetics find new and known acne vulgaris risk loci with a genome-wide association study and meta-analysis, highlighting hair follicle- and metabolic disease-related genes.

Retina Cell Loss Reversed by Prime Editing in Mouse Model of Retinitis Pigmentosa

A team from China turns to prime editing to correct a retinitis pigmentosa-causing mutation in the PDE6b gene in a mouse model of the progressive photoreceptor loss condition in the Journal of Experimental Medicine.

CRISPR Screens Reveal Heart Attack-Linked Gene

Researchers in PLOS Genetics have used CRISPR screens to home in on variants associated with coronary artery disease that affect vascular endothelial function.