This Week in Nature

In Nature this week, Stanford University scientists led by 2012 Nobel Laureate Brian Kobilka publish the structure of a human G-protein-coupled receptor bound to a drug. Specifically, they showed the crystal structure of the coagulation-mediating human protease-activated receptor 1 associated with vorapaxar, a PAR1 antagonist under clinical development for the prevention of cardiovascular events in patients with a history of heart attacks.

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