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This Week in Nature: Oct 19, 2012

In Nature this week, researchers from the International Barley Genome Sequencing Consortium publish an integrated and ordered physical, genetic, and functional sequence resource describing the barley gene-space. Genomes from the crops of the Triticeae tribe, which includes rye, wheat, and barley, have proven difficult to sequence given their size and complexity. To address this issue, the consortium scientists combined multiple genomic and genetic datasets to create "an integrated, multi-layered informational resource that provides access to the majority of barley genes in a highly structured physical and genetic framework." This provides other investigators with a platform for genome-assisted research and contemporary crop improvement.

In Nature Communications, a Harvard Medical School-led team reports data genetically linking populations in eastern and southern Africa, providing evidence that both locations were origins of modern humans. The investigators examined more than 500,000 single-nucleotide polymorphisms from 21 southern African and two eastern African groups using a genome-wide array, and found that they share a quarter of their ancestry despite their geographical isolation. The team suggests that separation of the populations began within the last 30,000 years, and shows a genetic signature of population mixture between the populations and northern migrants beginning 1,200 years ago.

Finally, in Nature Methods, scientists from Utrecht University and Thermo Fisher Scientific describe an approach for improving the resolution and accessibility of mass spectrometry methods for determining the structural details of large multi-protein complexes. By modifying an Orbitrap mass spectrometer, the group was able to measure intact multi-protein complexes with molecular weights up to 1,000 kDa with sensitivity sufficient to detect single ions. The instrumental modifications are minor, and are expected to allow more "in-depth and detailed information to be gained than is currently possible with native mass spectrometry."

The Scan

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Nature Papers Review Integration of Single-Cell Assay Data, Present Approach to Detect Rare Variants

In Nature this week: review of ways to integrate data from single-cell assays, and more.