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This Week in Nature: Aug 23, 2012

In this week's Nature, Decode Genetics researchers publish genome sequencing data showing that children of older fathers have a higher de novo mutation rate. "Most notably, the diversity in mutation rate of single nucleotide polymorphisms is dominated by the age of the father at conception of the child," the researchers write, and the effect translates to about two mutations for every additional year of the father's age. The results suggest that father's age could increase the risk of conditions such as schizophrenia and autism.

Elsewhere, a team led by researchers from the International Rice Research Institute in the Philippines reports on the characterization of a gene that can enhance rice yields in crops that typically require phosphorus fertilizer. Additional analysis shows that the gene, dubbed phosphorus-starvation tolerance 1, or PSTOL1, enhances early root growth, enabling plants to acquire more phosphorus and other nutrients. Introducing this gene into various rice varieties could, the team says, "considerably enhance productivity under low phosphorus conditions."

Also in Nature, University of Washington in Seattle researchers detail the discovery that mice with only a single functional copy of the SCN1A gene, which encodes the voltage-gated sodium channel Nav1.1, display autism-like behavior. The findings indicate that Dravet's syndrome, a childhood epilepsy disorder caused by dysfunction of this sodium channel, is associated with the autistic and cognitive symptoms observed in patients. The mutation that impairs Nav1.1 also negatively affects GABA neurotransmission in the brain, and when mice were treated with clonazepam, a known positive modulator of GABA receptors, the autistic behavior is eliminated, suggesting a "potential therapeutic strategy for cognitive deficit and autism-spectrum behaviors in Dravet's syndrome," the researchers write.

The Scan

Booster Push

New data shows a decline in SARS-CoV-2 vaccine efficacy over time, which the New York Times says Pfizer is using to argue its case for a booster, even as the lower efficacy remains high.

With Help from Mr. Fluffington, PurrhD

Cats could make good study animals for genetic research, the University of Missouri's Leslie Lyons tells the Atlantic.

Man Charged With Threatening to Harm Fauci, Collins

The Hill reports that Thomas Patrick Connally, Jr., was charged with making threats against federal officials.

Nature Papers Present Approach to Find Natural Products, Method to ID Cancer Driver Mutations, More

In Nature this week: combination of cryogenic electron microscopy with genome mining helps uncover natural products, driver mutations in cancer, and more.