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This Week in Nature: Sep 13, 2007

In Nature, an editorial argues that in the age of 'omic science and increasingly interdisciplinary research, the peer-review process for grant applications at the NIH needs a complete overhaul.

A commentary adds fuel to the fire of today's funding problems for biomedical research, in which Brian Martinson debated the question, "What is it that poses the most potent threat to the future of biomedical research — a lack of resources, or our failure to manage the level of competition for available resources?"

Researchers at Emory have resolved the structure of one DNA methyltransferase, Dnmt3a, in a complex with its regulatory factor Dnmt3L, confirming that successful DNA methylation must have Dnmt3a and Dnmt3L working as a team. A related commentary says, "The central Dnmt3a dimer in the tetramer can methylate two CG dinucleotides in one binding event, and that it preferentially methylates pairs of CGs that are 8-10 base pairs apart, with other CGs in between remaining unmethylated."

 

The Scan

For Better Odds

Bloomberg reports that a child has been born following polygenic risk score screening as an embryo.

Booster Decision Expected

The New York Times reports the US Food and Drug Administration is expected to authorize a booster dose of the Pfizer-BioNTech SARS-CoV-2 vaccine this week for individuals over 65 or at high risk.

Snipping HIV Out

The Philadelphia Inquirer reports Temple University researchers are to test a gene-editing approach for treating HIV.

PLOS Papers on Cancer Risk Scores, Typhoid Fever in Colombia, Streptococcus Protection

In PLOS this week: application of cancer polygenic risk scores across ancestries, genetic diversity of typhoid fever-causing Salmonella, and more.