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A team led by investigators at the University of Rochester in New York this week show that "nuclear-retained transcripts containing expanded CUG-CUGexp — repeats are unusually sensitive to antisense silencing," and that, in a transgenic mouse model of myotonic dystrophy type 1, the systematic administration of antisense oligonucleotides causes "a rapid knockdown of CUGexpRNA in skeletal muscle, correcting the physiological, histopathologic and transcriptomic features of the disease." Overall, as the Rochester-led team reports in Nature, "these results provide

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Springer Nature announces €9,500 fee to make papers open-access in Nature and its family of journals.

Librarians have concluded that notebooks that belonged to Charles Darwin that were thought to have been lost were actually likely stolen, CNN reports.

An early SARS-CoV-2 alteration may have enabled it to spread more easily, according to the New York Times.

In PNAS this week: ultrarare variants contribute to aging-related hearing loss, telomeres of cells infected with herpesvirus, and more.