An international team led by investigators at the Broad Institute this week reports whole-exome sequences for 103 human breast cancers of diverse subtypes and matched-normal DNA as well as whole-genome sequences for 22 breast cancer/normal pairs. In its analysis of these sequences, the team confirmed recurrent somatic mutations in PIK3CA11, TP536, AKT112, GATA313, and MAP3K110 in the cancer samples and identified recurrent mutations in the CBFB transcription factor gene and deletions of its partner, RUNX1.