This Week in Nature

Memorial Sloan-Kettering Cancer Center's Duncan Smith and Iestyn Whitehouse show that in Saccharomyces cerevisiae ligation-competent Okazaki fragments are sized according to the nucleosome repeat, and that "ligation junctions preferentially occur near nucleosome midpoints rather than in internucleosomal linker regions."

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The US Food and Drug Administration has approved Alnylam's RNAi-based therapy Onpattro, according to Stat News.

Harvard Medical School's Seth Cassel and Cigall Kadoch argue in a Baltimore Sun op-ed that the recent TAILORx trial shows the potential of genomic-based medicine.

Researchers in the UK are working on using gene drives to control malaria-carrying mosquitoes, the Telegraph reports.

In PLOS this week: genetic architecture mediating gene expression, metabolomic patterns in multiple myeloma, and more.