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This Week in Nature: Mar 15, 2012

Memorial Sloan-Kettering Cancer Center's Duncan Smith and Iestyn Whitehouse show that in Saccharomyces cerevisiae ligation-competent Okazaki fragments are sized according to the nucleosome repeat, and that "ligation junctions preferentially occur near nucleosome midpoints rather than in internucleosomal linker regions."

In another Nature paper published online in advance this week, an international team led by investigators at the Technical University of Munich reports its "high-yield production of plasmonic structures that contain nanoparticles arranged in nanometre-scale helices," based on DNA origami. The team also reports having found that, in solution, its structures "exhibit defined circular dichroism and optical rotatory dispersion effects at visible wavelengths that originate from the collective plasmon-plasmon interactions of the nanoparticles positioned with an accuracy better than two nanometres."

Researchers at the University of Gothenburg and elsewhere this week show in mice that "the microbiota-induced extravascular TF [tissue factor]-PAR1 signalling loop is a novel pathway that may be modulated to influence vascular remodeling in the small intestine." The Gothenburg-led team shows in Nature this week that "mice with a genetic deletion of the TF cytoplasmic domain or with hypomorphic TF alleles had a decreased intestinal vessel density."

The Scan

Fertility Fraud Found

Consumer genetic testing has uncovered cases of fertility fraud that are leading to lawsuits, according to USA Today.

Ties Between Vigorous Exercise, ALS in Genetically At-Risk People

Regular strenuous exercise could contribute to motor neuron disease development among those already at genetic risk, Sky News reports.

Test Warning

The Guardian writes that the US regulators have warned against using a rapid COVID-19 test that is a key part of mass testing in the UK.

Science Papers Examine Feedback Mechanism Affecting Xist, Continuous Health Monitoring for Precision Medicine

In Science this week: analysis of cis confinement of the X-inactive specific transcript, and more.